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Search Results for " hek 5 "

Targets Recommended: Dopamine Receptor 5-HT Receptor Adrenergic Receptor Norepinephrine Histamine Receptor

10

抑制剂 & 化合物

13

重组蛋白

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Cat. No.	Product Name	Target	Signaling Pathways
T0031L2	Ziprasidone 齐拉西酮,Geodon,Zeldox,CP-88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone (Geodon) 是一种联合的 5-HT(5-羟色胺)和多巴胺受体拮抗剂，具有强大的抗精神病活性。它是去甲肾上腺素再摄取抑制剂，对大鼠和人的5-HT1A，5-HT2A 和多巴胺 D2 受体有很高的亲和力。
T0031	Ziprasidone hydrochloride monohydrate 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059	Dopamine Receptor; 5-HT Receptor; Adrenergic Receptor; Norepinephrine; Histamine Receptor	GPCR/G Protein; Immunology/Inflammation; Neuroscience
	Ziprasidone hydrochloride monohydrate (CP 88059) 是一种联合 5-HT（5-羟色胺）和多巴胺受体拮抗剂，具有抗精神病活性的强效作用。它也是去甲肾上腺素再摄取抑制剂。
T60523	Agomelatine hydrochloride S-20098 hydrochloride	MT Receptor	Neuroscience
	Agomelatine hydrochloride (S-20098 hydrochloride) (S-20098 hydrochloride) 是特异性的MT1和MT2受体激动剂，对 CHO-hMT1的Ki 值为0.1 nM，对HEK-hMT1的Ki 值为0.06 nM，对CHO-hMT2的Ki 值为0.12 nM，对HEK-hMT2 的Ki 值为0.27 nM。Agomelatine hydrochloride 是选择性的5-羟色胺2C(5-HT2C)受体拮抗剂，对天然 (猪) 和克隆的人 5-HT2C 受体的pKi 值分别为 6.4 和 6.2。
T9019	JHU37152 JHU 37152	AChR	Neuroscience
	JHU37152 (JHU 37152) 是一种可透过血脑屏障的DREADD 激动剂。在 HEK-293 细胞的荧光和基于 BRET 的测定中，对hM3Dq 和hM4Di DREADDs 的EC50值分别为 5 和 0.5 nM。
T2092	Amitifadine hydrochloride DOV-21947 hydrochloride,EB-1010 hydrochloride	Dopamine Receptor; 5-HT Receptor; Serotonin Transporter; Norepinephrine	GPCR/G Protein; Neuroscience
	Amitifadine hydrochloride (EB-1010 hydrochloride) 是一种 5-羟色胺-去甲肾上腺素-多巴胺的再摄取抑制剂(SNDRI)，其在 HEK 293 细胞中测得的 IC50值分别为 12， 23， 96 nM。
T14190	Alniditan Alnitidan	5-HT Receptor	GPCR/G Protein; Neuroscience
	Alniditan is a receptors agonist of 5-HT1B/1D in HEK 293 cells (IC50: 1.7 and 1.3 nM). For 5-HT1B/1D receptors, the pKi values are 8.96 and 9.40, respectively.
T10267	Agomelatine (L(+)-Tartaric acid) 阿戈美拉汀 L(+)-酒石酸,S-20098 L(+)-Tartaric acid	5-HT Receptor	GPCR/G Protein; Neuroscience
	Agomelatine (S-20098) L(+)-Tartaric acid is a specific agonist of MT1 and MT2 receptors (Kis: 0.1, 0.06, 0.12, and 0.27 nM for CHO-hMT1, HEK-hMT1, CHO-hMT2, and HEK-hMT2). It also is a selective 5-HT2C receptor antagonist (pKis: 6.4 and 6.2 at native (porcine) and cloned (human) 5-HT2C receptors).
T62081	Mt KARI-IN-5
	Mt KARI-IN-5 (compound 6c) 是一种结核分歧杆菌酮醇酸还原异构酶 I (MtbKARI) 的有效抑制剂 (Ki: 4.72 μM)。Mt KARI-IN-5 对 MtbH37Rv 的活性表现出抑制作用，其 MIC 值为 1.56 μM，细胞毒性较低，对 HEK 的 IC50 值大于 64 μg/mL。
T63643	BI-4142	HER	Angiogenesis; JAK/STAT signaling; Tyrosine Kinase/Adaptors
	BI-4142 是一种具有口服活性、高效和选择性的 HER2 抑制剂，抑制癌细胞增殖，抑制her2依赖性细胞系并抑制下游信号传导。
T72830	TLR8 agonist 5
	TLR8 agonist5 是有效的 TLR8激动剂，对 HEK-Blue hTLR8 的 EC50值为 20 nM。TLR8 agonist5 激活免疫反应。

化合物

Cat.No: T0031L2

Synonym: 齐拉西酮,Geodon,Zeldox,CP-88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Ziprasidone hydrochloride monohydrate

Cat.No: T0031

Synonym: 齐拉西酮盐酸盐一水合物,盐酸齐拉西酮水合物,CP 88059

Target: Dopamine Receptor, 5-HT Receptor, Adrenergic Receptor, Norepinephrine, Histamine Receptor

Agomelatine hydrochloride

Cat.No: T60523

Synonym: S-20098 hydrochloride

Target: MT Receptor

Cat.No: T9019

Synonym: JHU 37152

Target: AChR

Amitifadine hydrochloride

Cat.No: T2092

Synonym: DOV-21947 hydrochloride,EB-1010 hydrochloride

Target: Dopamine Receptor, 5-HT Receptor, Serotonin Transporter, Norepinephrine

Cat.No: T14190

Synonym: Alnitidan

Target: 5-HT Receptor

Agomelatine (L(+)-Tartaric acid)

Cat.No: T10267

Synonym: 阿戈美拉汀 L(+)-酒石酸,S-20098 L(+)-Tartaric acid

Target: 5-HT Receptor

Cat.No: T62081

Cat.No: T63643

Target: HER

Cat.No: T72830

Species：

Expression System：

Tag：

Cat. No.	Product Name	Species	Expression System
TMPY-01784	EphB3 Protein, Mouse, Recombinant (His) MDK5,Tyro6,Etk2,HEK2,EPH receptor B3,Cek10...	Mouse	HEK293 Cells
	EphB3 Protein, Mouse, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57 kDa and the accession number is P54754.
TMPK-00563	EPHB2 Protein, Cynomolgus, Recombinant (His) DRT,Nuk,Sek3,TYRO5,EPHT3,HEK5,Eph...	Cynomolgus	HEK293 Cells
	EphB2, a receptor tyrosine kinase for ephrin ligands, is overexpressed in various cancers and plays an important role in tumor progression. EPHB2 promotes endothelial-mesenchymal transition (EMT) and elicits associated pathologic characteristics of glioblastoma multiforme (GBM) such as invasion and migration. EPHB2 is epigenetically overexpressed in hypoxia, a condition highly prevalent in malignancy. Furthermore, HIF-2α is required for EPHB2 stabilization by hypoxia.
TMPK-00898	EphB3 Protein, Human, Recombinant (His) EC 2.7.10.1,EPHB3,ETK2,EK2,HEK2,AW45689	Human	HEK293 Cells
	Although EphB3 expression is down-regulated in colorectal cancer (CRC) cells compared with normal intestinal epithelial cells.EphB3 is down-regulated in CRC compared to normal mucosa. Hypermethylation of CpG island is contributed to downregulation of EphB3 in CRC. EphB3 expression in tumor cells may be a useful prognostic indicator for patients with CRC.
TMPY-00549	Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) Harvey rat sarcoma viral oncogene homolog	H5N1	HEK293 Cells
	Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 60 kDa and the accession number is B7NWR4.
TMPY-00595	Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) Harvey rat sarcoma viral oncogene homolog	H5N1	HEK293 Cells
	Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 38 kDa and the accession number is B7NWR4.
TMPY-05308	CD45 Protein, Human, Recombinant (aa 1-529, His) GP180,B220,L-CA,protein tyrosine phosphatase, receptor type,...	Human	HEK293 Cells
	CD45 Protein, Human, Recombinant (aa 1-529, His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 57.4 kDa and the accession number is P08575-5.
TMPY-05387	SLAMF7 Protein, Human, Recombinant (hFc) SLAM family member 7,19A,SLAM7,CS1,CD319,CRACC	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPY-04318	GRIK2 Protein, Human, Recombinant (hFc) GLUR6,EAA4,MRT6,GLR6,glutamate receptor, ionotropic, kainate...	Human	HEK293 Cells
	GRIK2 (Glutamate Ionotropic Receptor Kainate Type Subunit 2, also known as GluR6) is a Protein Coding gene. The GRIK2 (one of the kainate receptors) gene resides in a genetic linkage region (6q21) associated with bipolar disorder (BPD). The gene coding for GRIK2 has been suggested as a candidate gene for autism based on its localization in the autism-specific region on chromosome 6q21 and the involvement of receptor protein in cognitive functions like learning and memory. GRIK2 belongs to the gl...
TMPY-05547	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated CS1,SLAM7,CD319,SLAM family member 7,CRACC,19A	Human	HEK293 Cells
	SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 49.1 kDa and the accession number is Q9NQ25-5.
TMPJ-00854	ETS1 Protein, Human, Recombinant (His) V-ets Erythroblastosis Virus E26 Oncogene Homolog 1 (Avian),...	Human	E. coli
	ETS1 Protein (ETS1) is a nuclear protein that belongs to the ETS family. Members of this family recognize the core consensus DNA sequence GGAA/T in target genes. Proteins function either as transcriptional activators or repressors of numerous genes. They are involved in stem cell development, cell senescence and death, and tumorigenesis. ETS1 is a transcription factor, containing one ETS DNA-binding domain and one PNT (pointed) domain. it has been shown to interact with TTRAP, UBE2I and Death As...
TMPY-05498	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) HDLQTL6,SR-BI,SRB1,CD36L1,CLA-1,CLA1,scavenger receptor clas...	Human	HEK293 Cells
	SR-BI/SCARB1 Protein, Human, Recombinant (hFc) is expressed in HEK293 mammalian cells with hFc tag. The predicted molecular weight is 73.4 kDa and the accession number is Q8WTV0-5.
TMPK-01357	SIRP alpha V5 Protein, Human, Recombinant (His & Avi) MFR,PTPNS1,P84,BIT,MYD-1,MYD1,SHPS-1,SIRPA,SIRP α,SIRP α V	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.
TMPK-01363	SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated SIRP alpha,MFR,PTPNS1,SIRP α V5,P84,SHPS-1,BIT,CD17...	Human	HEK293 Cells
	Signal regulatory protein α (SIRPα) is a regulatory membrane glycoprotein from SIRP family expressed mainly by myeloid cells and also by stem cells or neurons.SIRPα acts as inhibitory receptor and interacts with a broadly expressed transmembrane protein CD47 also called the "don´t eat me" signal.Cancer cells highly expressed CD47 that activate SIRP α and inhibit macrophage-mediated destruction. SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated is expressed in HEK293 mammalian c...

重组蛋白

EphB3 Protein, Mouse, Recombinant (His)

Cat.No: TMPY-01784

Species: Mouse

Expression System: HEK293 Cells

EPHB2 Protein, Cynomolgus, Recombinant (His)

Cat.No: TMPK-00563

Species: Cynomolgus

Expression System: HEK293 Cells

EphB3 Protein, Human, Recombinant (His)

Cat.No: TMPK-00898

Species: Human

Expression System: HEK293 Cells

Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA Protein (HEK293, His)

Cat.No: TMPY-00549

Species: H5N1

Expression System: HEK293 Cells

Influenza A H5N1 (A/common magpie/Hong Kong/5052/2007) Hemagglutinin/HA1 Protein (HEK293, His)

Cat.No: TMPY-00595

Species: H5N1

Expression System: HEK293 Cells

CD45 Protein, Human, Recombinant (aa 1-529, His)

Cat.No: TMPY-05308

Species: Human

Expression System: HEK293 Cells

SLAMF7 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05387

Species: Human

Expression System: HEK293 Cells

GRIK2 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-04318

Species: Human

Expression System: HEK293 Cells

SLAMF7 Protein, Human, Recombinant (hFc), Biotinylated

Cat.No: TMPY-05547

Species: Human

Expression System: HEK293 Cells

ETS1 Protein, Human, Recombinant (His)

Cat.No: TMPJ-00854

Species: Human

Expression System: E. coli

SR-BI/SCARB1 Protein, Human, Recombinant (hFc)

Cat.No: TMPY-05498

Species: Human

Expression System: HEK293 Cells

SIRP alpha V5 Protein, Human, Recombinant (His & Avi)

Cat.No: TMPK-01357

Species: Human

Expression System: HEK293 Cells

SIRP alpha V5 Protein, Human, Recombinant (His & Avi), Biotinylated

Cat.No: TMPK-01363

Species: Human

Expression System: HEK293 Cells

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